About GABA

Gamma-aminobutyric acid, or GABA, is a substance that bodybuilders and other athletes sometimes use when looking for a competitive edge. It is an amino acid that serves as a neurotransmitter in the brain.

GABA acts on the pituitary gland, which controls synthesis of growth hormone and also plays a role in body temperature and sleep cycles. GABA supplements increase growth hormone levels, facilitate muscle recovery, relieve anxiety and induce sleep. The results that athletes hope for are more lean muscle tissue and lower body fat levels.

GABA was discovered in 1950 and has since been recognized as the dominant inhibitory neurotransmitter in the brain. There are excitatory neurotransmitters as well, like adrenaline, which, in excess, can lead to anxiety, insomnia, and restlessness.

The brain balances these effects by sending out other neurotransmitters that have calming effects, such as GABA. By inhibiting the action of excitatory neurotransmitters and reducing anxiety and restlessness, GABA promotes relaxation and sleepiness, and thus, as a supplement, can be a fantastic aid for people who suffer from insomnia and anxiety.

To understand how GABA influences a person’s sleeping patterns, it’s important that you understand the standard cycle that the brain undergoes each night during sleep. The following is an overview of the different sleep stages.

  • Stage 1 is when you’re getting sleepy and are ready to drift off.
  • Stage 2 – Your brainwave activity quickens and follows a steadier rhythm. Your core temperature and heart rate decrease.
  • Stage 3 sees the emergence of deeper, slower brain waves. Here, you switch from light sleep to deep sleep.
  • Stage 4 is the deep sleep stage, also known as delta sleep. This is a vitally important stage because it’s where much of the highest-quality sleep occurs.
  • Stage 5 is the REM (rapid-eye movement) stage, where most dreams occur.

The third and fourth stage are arguably the most important. Stage three, the slow-wave sleep stage, is important because it reduces the level of cortisol, the stress hormone, in the body, and simultaneously reduces inflammation. Both of these are important for improving your nightly sleep.

The fourth stage, deep sleep, is important because it helps your immune system grow stronger. In a similar manner that your brain commits things to memory, your immune system “memorizes” pathogens and viruses to memory during this phase.

Getting a proper sleep cycle each night is crucial for optimal health, and the brain’s GABA system is primarily responsible for activating each stage. Activated GABA receptors—which require a source of GABA to actually be activated—promote quality sleep, especially in stages three and four.

ProSupps CRASH contains GABA therefore it promotes deep REM sleep which increases growth hormone levels and helps with muscle recovery. Available at @wawanbahrain

About glucosamine

Glucosamine

Glucosamine is a compound naturally found within the cartilage of our joints, made from chains of sugars and proteins bound together. It acts as one of the body’s natural shock-absorbents and joint lubricants. Glucosamine possesses natural anti-inflammatory and anti-aging properties. One of the most popular supplements taken by people with bone and joint pain glucosamine aids in treating common symptoms of age-related disorders like arthritis and osteoarthritis.

Using glucosamine supplements or obtaining it from natural sources increases the amount of cartilage and fluid that surrounds our joints. This helps prevent joint breakdown and reduces pain.

Glucosamine slows down deterioration of joints when used long-term, plus it offers other benefits that prescription painkillers cannot (such as lowering chronic inflammation and improving digestive health).

Chondroitin

Chondroitin is a natural substance found in the human body and a major component of cartilage, which helps build connective tissue throughout the body. Because it works by retaining water, it helps add lubrication and flexibility to tissue and joints.

Chondroitin used with glucosamine helps lower symptoms associated with loss of collagen and cartilage, which are found in tendons, joints, ligaments, skin and the digestive tract. These conditions can include tendonitis, bursitis and so on. In healthy people, when cartilage becomes damaged due to overuse, injury or inflammation, new cartilage is normally produced to take its place. Unfortunately, as we get older our ability to regenerate lost cartilage and repair damaged connective tissue becomes less efficient.

In both humans and animals, glucosamine and chondroitin stimulate the production of new cartilage and can also help reduce inflammation in the process.

Source: https://draxe.com/chondroitin/

About L-glutamine

L-glutamine is the most abundant amino acid in the bloodstream.

L-glutamine benefits the body in the following ways:

1. Improves gastrointestinal health because it is a vital nutrient for the intestines to rebuild and repair

2. Helps heal ulcers and leaky gut by acting as a Band-Aid for protection from further damage

3. Is an essential neurotransmitter in the brain and helps with memory, focus and concentration (

4. Improves IBS and diarrhoea by balancing mucus production, which results in healthy bowel movements

5. Promotes muscle growth and decreases muscle wasting

6. Improves athletic performance and recovery from endurance exercise

7. Improves metabolism and cellular detoxification

8. Curbs cravings for sugar and alcohol

9. Fights cancer

10. Improves diabetes and blood sugar

Doing approximately one hour of exercise can cause a 40 percent reduction of glutamine in the body. It can also cause suppressed immune function. This has a negative impact on your resistance training and may lead to overtraining syndrome.

Supplementing with L-glutamine allows your muscles to fight and push a bit further, which boosts your strength and helps repair your skeletal muscles.

L-glutamine supplementation makes it possible to recover quicker from intense weight training sessions because it improves muscle hydration. This aids the muscle recovery process and reduces recovery time for wounds and burns.

L-glutamine also burns fat and builds lean muscle mass by helping suppress insulin levels and stabilize blood glucose. This enables the body to use up less muscle mass to maintain blood sugar and insulin sensitivity in the cells. For this reason, L-glutamine benefits diabetics and those with sugar and carb cravings as well.

About beta-alanine

Beta-alanine is a non-essential amino acid. It is not used by the body to synthesize proteins. Instead, together with histidine, it produces carnosine.

Carnosine reduces lactic acid accumulation in your muscles during exercise, which leads to improved athletic performance.

In muscles, histidine levels are normally high and beta alanine levels are normally low, which limits the carnosine production.

Since beta alanine supplements increase carnosine levels in muscles, they help the muscles reduce their acid levels during exercise. This leads to reduced fatigue.

Beta-alanine improves athletic performance. It can reduce fatigue, increase endurance and boost performance in high-intensity exercises.

In general, muscle acidosis limits the duration of high-intensity exercise.

For this reason, beta-alanine specifically helps performance during high-intensity and short-duration exercise lasting one to several minutes.

It’s possible that beta-alanine improves body composition by increasing training volume and promoting muscle growth

L-carnosine’s health benefits are generally due to its antioxidant properties, which support many age-related conditions. The specific uses of L-carnosine include support for the skin, joints, digestive system and memory. Carnosine also prevents changes in the structure and function of proteins in the body. This may give it some anti-aging properties.

Moreover, carnosine seems to elevate nitric oxide production. This may help against the aging process and improve immune function.

Lastly, carnosine increases the quality and function of muscles in the elderly.

It is generally recommended to consume 2-5 grams of beta-alanine daily. Taking it with a meal may be even more effective.

The most common side effect of beta-alanine is paraesthesia.

This is an unusual sensation typically described as “tingling of the skin.” It’s usually experienced in the face, neck and back of the hands.

The intensity of this tingling increases with dosage size. It usually starts with doses of 800 mg or higher, and disappears 60–90 minutes after consumption. But there is no evidence that paraesthesia is harmful in any way.

Wawan WBCAA recovery contains 1.8gr of Beta-Alanine, 10gr of BCAAs and 2.5gr of L-Glutamine, with 12gr of carbs – it makes it a perfect intra workout drink.

About the different types of proteins

There are 4 common types of protein:

  • When protein concentrate
  • Whey protein isolate
  • Hydrolysed whey protein
  • Casein protein

All whey proteins are easily digestible, therefore they break down in your body quickly, hence they can be a very essential part of your breakfast (after the fasting hours of your night sleep), and after your workout.

Whey protein concentrate is one of the most basic forms of protein.  This is probably the most common protein for anyone who works out. This is a great starting point for beginners, it’s slightly cheaper than the other types and it does the job. It has around 75-80% of protein in it (which means in a 100gr of powder you get 75-80 gr of protein), and it’s reasonably low in fat and carbs. However some people might have some gastric discomfort from this protein especially if they have any digestive issues already. For those people I recommend they try the other types of protein below.

The next level is the whey protein isolate. This protein has been filtered further than the concentrate, and therefore it’s lower in carbs and fats, lactose has been removed as well, therefore it usually doesn’t give any digestive issues. Its protein content is a bit higher, too, you can expect about 85-90% of protein in 100 gr of powder.

Hydrolysed whey protein is the clearest form of protein. It has no fat or carb content, therefore it’s almost 100% protein (around 90-95%). It’s very quick to absorb in the body.

Casein protein is different from whey protein. It breaks down slower in your body, over the course of 5-7 hours therefore it makes it a great ‘snack’ before you go to sleep. It also has high glutamine content, which is great for recovery.

WAWAN ISO Tamrya is made from EU sourced grass fed Cross-Flow Microfiltered Whey Protein Isolate, which makes it a great choice for breakfast or after workout.

About diabetes – part 1

There are 3 main types of diabetes mellitus:

  • Type 1 Diabetes: results from the pancreas failing to produce enough insulin
  • Type 2 Diabetes: a condition of defective insulin signalling
  • Gestational Diabetes: a condition where women without previously diagnose diabetes exhibit high blood glucose levels during pregnancy.

When insulin isn’t produced or acts ineffectively, glucose remains circulating in the blood, leading to a condition known as hyperglycemia. Long term hyperglycemia can result in the dysfunction and failure of various organs and systems, including the eyes, kidneys, nerves, heart and blood vessels.

The key players in diabetes are the pancreas and the liver.

The pancreas is both an endocrine and exocrine gland.

Exocrine means that it’s a gland that release its contents through a tube from inside to outside the body. It helps with digestion by producing important enzymes that break down food, which allows the body to absorb the nutrients.

The endocrine function primarily involves the secretion of the 2 primary hormones relevant to diabetes management: insulin and glucagon.

Insulin increases the storage of glucose, fatty acids and amino acids in cells and tissues and is considered an anabolic hormone. Insulin is a key player in the storage and use of fuels within the body.

Disorders in insulin production and signalling have widespread and devastating effects on the body’s organs and tissues. Glucagon is a peptide hormone produced by alpha cells in the pancreas. The pancreas releases glucagon when blood sugar levels fall too low. It opposes the action of insulin by raising the concentration of glucose in the blood.

Dietary carbs are not essential, however, the body needs glucose. The brain typically needs about 130 gr of glucose every day. Not all glucose has to come from the diet because the liver has the ability to synthesise it.

The liver serves as a warehouse for glucose storage and production. It can also produce fatty acids under certain conditions.

As blood glucose and insulin levels increase, the liver increases its absorption of glucose. Glucose is stored as glycogen. The amount of glycogen stored depends on circulating insulin and glucose levels. When blood glucose levels drop, insulin production falls. The shortage of insulin signals the liver to release its assets by sending glucose back into the blood to keep the body nourished.

When carb intake is restricted, it lowers blood sugar and insulin levels. As insulin levels fall and energy is needed, fatty acids leave their respected fat cells and enter the bloodstream. From here they’re taken up by specific cells and metabolised. Ketone bodies are molecules created in the liver, that are pushed into the blood stream where they’re utilised by skeletal and heart muscles cells as fuel. Also, the brain begins to use ketones as an alternate fuel source when blood levels are high enough to cross the blood-brain barrier. When this happens a person is said to be in nutritional ketosis.

Ketogenic diets are very popular because they suppress insulin and that seems to be very effective in the treatment and management of obesity and T2D. However the severe restriction of carbs (often below 30 gr) may increase the potential for hypoglycaemia of people with T1D.

Lipogenesis is creating fat within the body from glucose or other substrates. It takes place mostly in the liver. Lipogenesis occurs in the liver during times of calorific excess and overfeeding. The liver converts excess glucose to fatty acids. These fatty acids can be stored in the liver or transported via lipoproteins (carriers) to muscle and fat tissue for future fuel use or storage. The ratio that is stored or used is highly dependent on energy intake vs. energy expenditure.

In a healthy liver, insulin halts the production of glucose and instead promotes glycogen storage or generates fatty acids during times of energy excess.

The liver of a person with T1D has no internal break system. Insulin deficiency allows glucose production in the liver to go uncontrolled leading to hyperglycaemia and ketoacidosis if unmanaged. When there’s not enough insulin available, glucose cannot enter the cells for use as energy. Therefore the liver produces even more glucose in an attempt to provide energy for the starved cells, but because insulin is not available, none of this glucose can enter the cells. It builds up and starves the cells even further. Consequently, administration of insulin medication is needed to facilitate the entry of glucose into cells.

Insulin increases glucose uptake in the liver by facilitating the creation of glycogen and decreases glucose output.

Prolonged elevations in insulin that result from an energy surplus increase the body’s ability to produce fat via the process of lipogenesis.

Source:

Phil Graham: Diabetic Muscle

About L-Carnitine

Taking L-Carnitine is known to:

  • Improve high-intensity work capacity
  • Increase athletic performance
  • Speed your recovery from intense exercise
  • Make your brain work better

Carnitine is an amino acid composite that is made of lysine and methionine. It is responsible for the transport of fat into the cells to be used for energy, therefore your body becomes more efficient in processing fuel and it will increase your energy levels.

Elevating carnitine will improve physical performance by burning more fat, sparing glycogen, clearing muscle lactate, and optimizing hormone levels.

For Carnitine to be effective, you need to make sure you have enough Omega-3 in your body. Omega-3s increase metabolic rate by increasing cell activity and fat burning. Carnitine is the delivery system for long chain fatty acids therefore the less carnitine you have in your body, the fewer fatty acids get into the cells, and you don’t burn them for energy. Instead they’re stored as fat. By elevating carnitine fat burning increases, you will have more energy and feel more motivated.

Carnitine fights visceral belly fat, that is known to be the toughest fat to loose. Raising your carnitine levels will fight this visceral belly fat gain because it increases fat burning.

Higher muscle carnitine levels help decrease pain, muscle damage and markers of metabolic stress from high intensity exercise by reducing lactic acid production, therefore you can have a greater work production because it will not feel as physically difficult.

Taking carnitine will also support an anabolic response to exercise by up-regulating the androgen receptors, which will speed up your recovery.

Carnitine can help prevent type 2 diabetes because of how it improves fat metabolism. It can counter the diseases of metabolic syndrome by supporting cardiovascular health while inducing fat loss.